Firms located in smarter cities present higher level of profitability. We use IESE Cities in Motion index (ICIM), as a proxy to compare smart cities, as well as the key indicators in representing an urban area as a smart city,for11 most populated cities in the US. We find that firms located in smarter cities are more profitable: on average a 1% higher ICIM of a smart city results in a 0.13% higher profitability of firms located in this city.